Yes, unlike Salesforce standard Change Sets, Copado Essentials can be used to deploy across unrelated organizations including production org, sandboxes, and developer edition org.
Copado Essentials license is per Copado Essentials user (not per org). This means a licensed user can deploy from any source organization to any target organization as long as those organizations can be authorized by the user.
Note that if you work for a consulting company, we recommend signing in essentials.copado.com via your own company's Salesforce account, rather than your client's Salesforce account, to allow you to work on multiple clients from a single org.